I received some information in another Forum following a question I asked with a number of points, one was the use of the Premium version of Malwarebytes which has the real-time protection. The information follows:
MBAM is pretty unique in that it does play well with other anti-programs, including Norton (which I am NOT a fan off - too bloated and too expensive without providing any real security advantage - but it does work).
That said, there is no problem with the free version of MBAM because that does not have the "real-time" scanner. It is "on-demand" only. In the olden days, running two real-times scanners would occasionally cause "conflicts" - I liken it to, "two dogs guarding the same bone, each wondering what the other is up to".
Today, most antimalware programs are well behaved so "conflicts" are not the issue. But wasted resources can be.
I do agree with using CCleaner, the free version is quite sufficient but there is an option to purchase the program.